The Microfluidic Sperm Sorting Method can increase the success rate of therapy by 20 – 25%

The selection of viable sperm is crucial for fertilizing an egg under laboratory conditions. Centrifugation is commonly used to separate sperm from the ejaculate, but it has the disadvantage of increasing oxidative stress on the sperm and the risk of DNA fragmentation, which can complicate the pregnancy process. Newer methods include magnetically activated sperm separation (MACS), which captures sperm with reduced fertilization capability. Currently, the most promising option is the microfluidic sperm separation method (MFSS). This method is gentler and can mimic the natural mechanism of sperm selection even in laboratory conditions. We are the first and only IVF clinic in the Czech Republic to have this method included in the standard therapy package without additional fees.

"Microfluidic separation can select the most suitable sperm to reach the egg without further processing of the ejaculate, even replicating the natural environment of the female reproductive system," explains Dr. Renata Hüttelová, head of the embryology laboratory at the IVF clinic CUBE in Prague. This method is now provided to patients free of charge as part of the standard IVF therapy package. According to previous studies, sperm sorted using this method show better motility, genetic quality, and morphology. The use of this method can increase the success rate of treatment in indicated cases by up to 20-25%.